叶方富研究员

        中国科学院物理研究所软物质与生物物理实验室主任、党支部书记，研究员、博士生导师。1999年获北京大学天文学及经济学双学士学位，2007年获美国宾夕法尼亚大学物理学博士学位，之后相继在美国肯特州立大学、伊利诺伊大学、佐治亚理工学院从事软物质与理论生物物理研究。2013年加入中国科学院物理研究所。承担多个国家基金委项目、国家重点研发计划课题、中国科学院战略性先导科技专项（B 类）等项目。目前主要从事生命活性物质、细胞动力学及功能生物材料等的研究工作，搭建了从软物质物理到功能生物材料的构建并最终使其服务于医学应用的桥梁，完成了从理论建模到仿生设计再到实际应用的系统化工作。相关工作在 Phys. Rev. Lett.、PNAS、Advanced Materials 等权威期刊上发表论文150多篇。担任中国物理学会软物质与生物物理专业委员会秘书长、中国液晶学会委员、Smart Medicine 副主编。

研究方向：统计物理及其在软物质和生命物质体系中的应用；胞外微环境对细胞力学的调控。

近年代表性工作[1-50]：

1.    Zhang, L., Parvin, R., Lin, S., Chen, M., Zheng, R., Fan, Q., and Ye, F., Peptide Nucleic Acid Clamp-Assisted Photothermal Multiplexed Digital PCR for Identifying SARS-CoV-2 Variants of Concern. Advanced Science, 2024. n/a(n/a): p. 2306088.
2.    Zheng, R.X., Zhang, L.X., Parvin, R., Su, L.H., Chi, J.J., Shi, K.Q., Ye, F.F., and Huang, X.Y., Progress and Perspective of CRISPR-Cas9 Technology in Translational Medicine. Advanced Science, 2023. 10(25).
3.    Zhang, Z.H., Yang, X.Y., Zhao, Y.J., Ye, F.F., and Shang, L.R., Liquid Crystal Materials for Biomedical Applications. Advanced Materials, 2023. 35(36).
4.    Zhang, Y., Wei, D., Wang, X., Wang, B., Li, M., Fang, H., Peng, Y., Fan, Q., and Ye, F., Run-and-tumble dynamics and mechanotaxis discovered in microglial migration. Research, 2023. 6: p. 0063.
5.    Zhang, L., Parvin, R., Chen, M., Hu, D., Fan, Q., and Ye, F., High-throughput microfluidic droplets in biomolecular analytical system: A review. Biosensors and Bioelectronics, 2023: p. 115213.
6.    Xu, P., Cao, T., Fan, Q., Wang, X., Ye, F., and Eiser, E., Whole-genome detection using multivalent DNA-coated colloids. Proceedings of the National Academy of Sciences, 2023. 120(37): p. e2305995120.
7.    Xie, R., Yu, X., Cao, T., Yang, C., Zhang, Y., Wang, X., Liu, Y.-J., Duan, S., Ye, F., and Fan, Q., Fibrous Viscoelastic Extracellular Matrix Assists Precise Neuronal Connectivity. Advanced Functional Materials, 2023. n/a(n/a): p. 2301926.
8.    Xiao, Y., Yi, H., Zhu, J., Chen, S., Wang, G., Liao, Y., Lei, Y., Chen, L., Zhang, X., and Ye, F., Evaluation of DNA adduct damage using G-quadruplex-based DNAzyme. Bioact Mater, 2023. 23: p. 45-52.
9.    Wang, Y., Li, J., Sun, L., Chen, H., Ye, F., Shang, L., and Zhao, Y., Liquid Metal Droplets-based Elastomers from Electric Toothbrush-inspired Revolving Microfluidics. Advanced Materials, 2023. n/a(n/a): p. 2211731.
10.    Wang, X., Li, H., Zheng, Y., Guan, D., Wang, A., Fan, Q., Jiao, Y., and Ye, F., Collective Organization Behaviors of Multi-Cell Systems Induced by Engineered ECM-Cell Mechanical Coupling. Advanced Functional Materials, 2023. n/a(n/a): p. 2305414.
11.    Shao, C., Yu, Y., Lei, X., Cao, J., Zhao, Y., and Ye, F., Organ-on-a-chip for dynamic tumor drug resistance investigation. Chemical Engineering Journal, 2023. 460: p. 141739.
12.    Shao, C., Cao, T., Wang, X., Fan, Q., and Ye, F., Reconstruction of the alveolar–capillary barrier in vitro based on a photo-responsive stretchable Janus membrane. Smart Medicine, 2023. 2(1): p. e20220035.
13.    Parvin, R., Zhang, L.X., Zu, Y., and Ye, F.F., Photothermal Responsive Digital Polymerase Chain Reaction Resolving Exosomal microRNAs Expression in Liver Cancer. Small, 2023. 19(28).
14.    Zhao, K., Liu, Y., Ren, Y., Li, B., Li, J., Wang, F., Ma, C., Ye, F., Sun, J., Zhang, H., and Liu, K., Molecular Engineered Crown-Ether-Protein with Strong Adhesion over a Wide Temperature Range from −196 to 200 °C. Angew Chem Int Ed Engl, 2022. 61(33): p. e202207425.
15.    Zhang, L., Rokshana, P., Yu, Y., Zhao, Y., and Ye, F., Near-Infrared Responsive Droplet for Digital PCR. Small, 2022: p. e2107858.
16.    Zhang, L., Parvin, R., Fan, Q., and Ye, F., Emerging digital PCR technology in precision medicine. Biosensors and Bioelectronics, 2022. 211: p. 114344.
17.    Zhang, L., Li, W., Parvin, R., Wang, X., Fan, Q., and Ye, F., Screening Prostate Cancer Cell-Derived Exosomal MicroRNA Expression with Photothermal-Driven Digital PCR. Adv. Funct. Mater., 2022. 32(48): p. 2207879.
18.    Ye, X., Yu, Y., Yang, C., Fan, Q., Shang, L., and Ye, F., Microfluidic electrospray generation of porous magnetic Janus reduced graphene oxide/carbon composite microspheres for versatile adsorption. Journal of Colloid and Interface Science, 2022. 624: p. 546-554.
19.    Ye, X., Fan, Q., Shang, L., and Ye, F., Adsorptive carbon-based materials for biomedical applications. Engineered Regeneration, 2022. 3(4): p. 352-364.
20.    Yang, C., Wang, X., Xie, R., Zhang, Y., Xia, T., Lu, Y., Ye, F., Zhang, P., Cao, T., Xu, Y., and Fan, Q., Dynamically Reconstructed Collagen Fibers for Transmitting Mechanical Signals to Assist Macrophages Tracing Breast Cancer Cells. Advanced Functional Materials, 2022. 33(9): p. 2211807.
21.    Wang, X., Xing, X., Lu, S., Du, G., Zhang, Y., Ren, Y., Sun, Y., Sun, J., Fan, Q., Liu, K., Wang, F., and Ye, F., Collective Cell Behaviors Manipulated by Synthetic DNA Nanostructures. Fundamental Research, 2022.
22.    Shao, C., Zhang, Q., Kuang, G., Fan, Q., and Ye, F., Construction and application of liver cancer models in vitro. Engineered Regeneration, 2022. 3(3): p. 310-322.
23.    Shao, C., Yu, Y., Fan, Q., Wang, X., and Ye, F., Polyurethane-polypyrrole hybrid structural color films for dual-signal mechanics sensing. Smart Medicine, 2022. 1(1): p. e20220008.
24.    Shang, L., Ye, F., Li, M., and Zhao, Y., Spatial confinement toward creating artificial living systems. Chem Soc Rev, 2022. 51(10): p. 4075-4093.
25.    Qi, X., Huang, Y., You, S., Xiang, Y., Cai, E., Mao, R., Pan, W., Tong, X., Dong, W., Ye, F., and Shen, J., Engineering Robust Ag-Decorated Polydopamine Nano-Photothermal Platforms to Combat Bacterial Infection and Prompt Wound Healing. Advanced Science, 2022. n/a(n/a): p. 2106015.
26.    Lou, X., Yang, Q., Ding, Y., Liu, P., Chen, K., Zhou, X., Ye, F., Podgornik, R., and Yang, M., Odd viscosity-induced Hall-like transport of an active chiral fluid. Proceedings of the National Academy of Sciences, 2022. 119(42): p. e2201279119.
27.    Liu, P., Ning, L., Zong, Y., Ye, F., Yang, M., and Chen, K., Lattice Induced Short-Range Attraction between Like-Charged Colloidal Particles. Physical Review Letters, 2022. 129(1): p. 018002.
28.    Liu, H., Zong, Y., Zu, M., Mason, T.G., Ye, F., and Zhao, K., Curvature-assisted self-assembly of Brownian squares on cylindrical surfaces. J Colloid Interface Sci, 2022. 605: p. 863-870.
29.    Zhang, X., Chen, G., Sun, L., Ye, F., Shen, X., and Zhao, Y., Claw-inspired microneedle patches with liquid metal encapsulation for accelerating incisional wound healing. Chemical Engineering Journal, 2021. 406: p. 126741.
30.    Ye, X., Shao, C., Fan, Q., Shang, L., and Ye, F., Porous carbon nanotube microspheres with tailorable surface wettability areas for oil adsorption. Journal of Colloid and Interface Science, 2021. 604: p. 737-745.
31.    Yang, Q., Zhu, H., Liu, P., Liu, R., Shi, Q., Chen, K., Zheng, N., Ye, F., and Yang, M., Topologically Protected Transport of Cargo in a Chiral Active Fluid Aided by Odd-Viscosity-Enhanced Depletion Interactions. Phys Rev Lett, 2021. 126(19): p. 198001.
32.    Yang, C., Wu, B., Ruan, J., Zhao, P., Chen, L., Chen, D., and Ye, F., 3D-Printed Biomimetic Systems with Synergetic Color and Shape Responses Based on Oblate Cholesteric Liquid Crystal Droplets. Advanced Materials, 2021. n/a(n/a): p. 2006361.
33.    Xu, D., Sun, L., Zhang, Z., Wang, Y., Zhang, X., Ye, F., Zhao, Y., and Pan, J., Bio-inspired Janus structural color films as visually flexible electronics. Applied Materials Today, 2021. 24: p. 101124.
34.    Wang, X., Yu, Y., Yang, C., Shao, C., Shi, K., Shang, L., Ye, F., and Zhao, Y., Microfluidic 3D Printing Responsive Scaffolds with Biomimetic Enrichment Channels for Bone Regeneration. Advanced Functional Materials, 2021. 31(40): p. 2105190.
35.    Shao, C., Chi, J., Shang, L., Fan, Q., and Ye, F., Droplet microfluidics-based biomedical microcarriers. Acta Biomater, 2021.
36.    Shao, C., Chi, J., Chen, Z., Sun, L., Shang, L., Zhao, Y., and Ye, F., Nano-imprinted anisotropic structural color graphene films for cardiomyocytes dynamic displaying. Materials Today, 2021. 51: p. 117-125.
37.    Ning, L., Liu, P., Ye, F., Yang, M., and Chen, K., Diffusion of colloidal particles in model porous media. Physical Review E, 2021. 103(2): p. 022608.
38.    Fan, Q., Zheng, Y., Wang, X., Xie, R., Ding, Y., Wang, B., Yu, X., Lu, Y., Liu, L., Li, Y., Li, M., Zhao, Y., Jiao, Y., and Ye, F., Dynamically Re-Organized Collagen Fiber Bundles Transmit Mechanical Signals and Induce Strongly Correlated Cell Migration and Self-Organization. Angew Chem Int Ed Engl, 2021. 60(21): p. 11858-11867.
39.    Chi, J., Shao, C., Shang, L., Zhao, Y., and Ye, F., Microfluidic droplet templates derived porous patch with anisotropic wettability. Chemical Engineering Journal, 2021. 417: p. 128073.
40.    Chen, L., Yang, C., Xiao, Y., Yan, X., Hu, L., Eggersdorfer, M., Chen, D., Weitz, D.A., and Ye, F., Millifluidics, microfluidics, and nanofluidics: manipulating fluids at varying length scales. Materials Today Nano, 2021. 16: p. 100136.
41.    Chen, L., Xiao, Y., Wu, Q., Yan, X., Zhao, P., Ruan, J., Shan, J., Chen, D., Weitz, D.A., and Ye, F., Emulsion Designer Using Microfluidic Three-Dimensional Droplet Printing in Droplet. Small, 2021. 17(39): p. e2102579.
42.    Yuan, Y., Brouchon, J., Calvo-Calle, J.M., Xia, J., Sun, L., Zhang, X., Clayton, K.L., Ye, F., Weitz, D.A., and Heyman, J.A., Droplet encapsulation improves accuracy of immune cell cytokine capture assays. Lab on a Chip, 2020. 20(8): p. 1513--1520.
43.    Sun, L., Yu, Y., Chen, Z., Bian, F., Ye, F., Sun, L., and Zhao, Y., Biohybrid robotics with living cell actuation. Chemical Society Reviews, 2020. 49(12): p. 4043--4069.
44.    Liu, P., Zhu, H., Zeng, Y., Du, G., Ning, L., Wang, D., Chen, K., Lu, Y., Zheng, N., Ye, F., and Yang, M., Oscillating collective motion of active rotors in confinement. Proceedings of the National Academy of Sciences, 2020. 117(22): p. 11901--11907.
45.    Liu, P., Ye, S., Ye, F., Chen, K., and Yang, M., Constraint Dependence of Active Depletion Forces on Passive Particles. Physical Review Letters, 2020. 124(15).
46.    Gimenez-Pinto, V. and Ye, F., Patterning order and disorder with an angle: modeling single-layer dual-phase nematic elastomer ribbons. RSC Advances, 2019. 9(16): p. 8994--9000.
47.    Cai, L., Wang, H., Yu, Y., Bian, F., Wang, Y., Shi, K., Ye, F., and Zhao, Y., Stomatocyte structural color-barcode micromotors for multiplex assays. National Science Review, 2019. 7(3): p. 644--651.
48.    Boromand, A., Signoriello, A., Lowensohn, J., Orellana, C.S., Weeks, E.R., Ye, F., Shattuck, M.D., and O\textquotesingleHern, C.S., The role of deformability in determining the structural and mechanical properties of bubbles and emulsions. Soft Matter, 2019. 15(29): p. 5854--5865.
49.    Boromand, A., Signoriello, A., Ye, F., O'Hern, C.S., and Shattuck, M.D., Jamming of Deformable Polygons. Physical Review Letters, 2018. 121(24).
50.    Fan, Q., Liu, R., Jiao, Y., Tian, C., Farrell, J.D., Diao, W., Wang, X., Zhang, F., Yuan, W., Han, H., Chen, J., Yang, Y., Zhang, X., Ye, F., Li, M., Ouyang, Z., and Liu, L., A novel 3-D bio-microfluidic system mimicking in vivo heterogeneous tumour microstructures reveals complex tumour\textendashstroma interactions. Lab on a Chip, 2017. 17(16): p. 2852--2860.