樊琪慧

开展的研究工作包括基于微流控技术以及天然水凝胶材料构建三维细胞培养模型、器官芯片等，用于模拟体内复杂微环境；同时在细胞、分子层面对微环境中的生物芯片模型进行追踪成像和物理调控，关注于三维微环境中力学信号对神经和肿瘤免疫等方面的细胞功能影响。结合物理、生命科学、工程等多学科领域的技术方法和理论，注重原始创新和开展高水平的研究工作，已在高影响期刊上发表文章50余篇。其中以第一/通讯作者身份发表论文30余篇，包括PNAS, Angew. Chem. Int. Ed., Adv. Funct. Mater., Adv. Sci., Lab on a Chip, Research, ACS Nano, Fundamental Research等。

主持国家自然基金委优青项目等3项，并入选中科院“青促会”；作为骨干成员，参与科技部重点研发项目、中科院科研仪器设备研制项目等。 

近期代表性一作/通讯文章 

1. Yang, C., Dong, X., Sun, B., Cao, T., Xie, R., Zhang, Y., Yang, Z., Huang, J., Lu, Y., Li, M., Wang, X., Xu, Y., Ye, F., and Fan, Q., Physical immune escape: Weakened mechanical communication leads to escape of metastatic colorectal carcinoma cells from macrophages. Proceedings of the National Academy of Sciences, 2024. 121(22): p. e2322479121. 

2. Zhang, L., Parvin, R., Lin, S., Chen, M., Zheng, R., Fan, Q., and Ye, F., Peptide Nucleic Acid Clamp-Assisted Photothermal Multiplexed Digital PCR for Identifying SARS-CoV-2 Variants of Concern. Advanced Science, 2024. p. 2306088. 

3. Zhang, Y., Wei, D., Wang, X., Wang, B., Li, M., Fang, H., Peng, Y., Fan, Q., and Ye, F., Run-and-Tumble Dynamics and Mechanotaxis Discovered in Microglial Migration. Research (Wash D C), 2023. 6(ja): p. 0063. 

4. Zhang, L., Parvin, R., Chen, M., Hu, D., Fan, Q., and Ye, F., High-throughput microfluidic droplets in biomolecular analytical system: A review. Biosensors and Bioelectronics, 2023: p. 115213. 

5. Xie, R.P., Yu, X.Y., Cao, T., Yang, C., Zhang, Y.Y., Wang, X.C., Liu, Y.J., Duan, S.M., Ye, F.F., and Fan, Q.H., Fibrous Viscoelastic Extracellular Matrix Assists Precise Neuronal Connectivity. Advanced Functional Materials, 2023. 33(36): p. 2301926. 

6. Wang, X., Li, H., Zheng, Y., Guan, D., Wang, A., Fan, Q., Jiao, Y., and Ye, F., Collective Organization Behaviors of Multi-Cell Systems Induced by Engineered ECM-Cell Mechanical Coupling. Advanced Functional Materials, 2023. n/a(n/a): p. 2305414. 

7. Shao, C., Cao, T., Wang, X., Fan, Q., and Ye, F., Reconstruction of the alveolar–capillary barrier in vitro based on a photo-responsive stretchable Janus membrane. Smart Medicine, 2023. 2(1): p. e20220035. 

8. Zhang, L.X., Parvin, R., Fan, Q.H., and Ye, F.F., Emerging digital PCR technology in precision medicine. Biosensors & Bioelectronics, 2022. 211. 

9. Zhang, L.X., Li, W.Z., Parvin, R., Wang, X.C., Fan, Q.H., and Ye, F.F., Screening Prostate Cancer Cell-Derived Exosomal MicroRNA Expression with Photothermal-Driven Digital PCR. Advanced Functional Materials, 2022. 32(48): p. 2207879. 

10. Ye, X., Yu, Y., Yang, C., Fan, Q., Shang, L., and Ye, F., Microfluidic electrospray generation of porous magnetic Janus reduced graphene oxide/carbon composite microspheres for versatile adsorption. Journal of Colloid and Interface Science, 2022. 624: p. 546-554. 

11. Ye, X., Fan, Q., Shang, L., and Ye, F., Adsorptive carbon-based materials for biomedical applications. Engineered Regeneration, 2022. 3(4): p. 352-364. 

12. Yang, C., Wang, X.C., Xie, R.P., Zhang, Y.Y., Xia, T., Lu, Y., Ye, F.F., Zhang, P.P., Cao, T., Xu, Y., and Fan, Q.H., Dynamically Reconstructed Collagen Fibers for Transmitting Mechanical Signals to Assist Macrophages Tracing Breast Cancer Cells. Advanced Functional Materials, 2023. 33(9): p. 2211807. 

13. Wang, X., Xing, X., Lu, S., Du, G., Zhang, Y., Ren, Y., Sun, Y., Sun, J., Fan, Q., Liu, K., Wang, F., and Ye, F., Collective Cell Behaviors Manipulated by Synthetic DNA Nanostructures. Fundamental Research, 2022. 

14. Shao, C., Chi, J., Shang, L., Fan, Q., and Ye, F., Droplet microfluidics-based biomedical microcarriers. Acta Biomater, 2022. 138: p. 21-33. 

15. Cao, T., Shao, C.M., Yu, X.Y., Xie, R.P., Yang, C., Sun, Y.L., Yang, S.H., He, W.J., Xu, Y., Fan, Q.H., and Ye, F.F., Biomimetic Alveolus-on-a-Chip for SARS-CoV-2 Infection Recapitulation. Research, 2022. 2022: p. 9819154. 

16. Ye, X., Shao, C., Fan, Q., Shang, L., and Ye, F., Porous carbon nanotube microspheres with tailorable surface wettability areas for oil adsorption. J Colloid Interface Sci, 2021. 604: p. 737-745. 

17. Fan, Q., Zheng, Y., Wang, X., Xie, R., Ding, Y., Wang, B., Yu, X., Lu, Y., Liu, L., Li, Y., Li, M., Zhao, Y., Jiao, Y., and Ye, F., Dynamically Re-Organized Collagen Fiber Bundles Transmit Mechanical Signals and Induce Strongly Correlated Cell Migration and Self-Organization. Angew Chem Int Ed Engl, 2021. 60(21): p. 11858-11867. 

18. Zheng, Y., Fan, Q.H., Eddy, C.Z., Wang, X.C., Sun, B., Ye, F.F., and Jiao, Y., Modeling multicellular dynamics regulated by extracellular-matrix-mediated mechanical communication via active particles with polarized effective attraction. Physical Review E, 2020. 102(5): p. 052409. 

19. Zheng, Y., Nan, H., Liu, Y.P., Fan, Q.H., Wang, X.C., Liu, R.C., Liu, L.Y., Ye, F.F., Sun, B., and Jiao, Y., Modeling cell migration regulated by cell extracellular-matrix micromechanical coupling. Physical Review E, 2019. 100(4): p. 043303. 

20. Fan, Q.H., Liu, R.C., Jiao, Y., Tian, C.X., Farrell, J.D., Diao, W.W., Wang, X.C., Zhang, F.R., Yuan, W., Han, H.B., Chen, J.F., Yang, Y., Zhang, X.X., Ye, F.F., Li, M., Ouyang, Z.C., and Liu, L.Y., A novel 3-D bio-microfluidic system mimicking in vivo heterogeneous tumour microstructures reveals complex tumour-stroma interactions. Lab on a Chip, 2017. 17(16): p. 2852-2860.