陆颖
2004年于北京工业大学获得学士学位。
2010年于中国科学院物理研究所获理学博士学位（导师：李明研究员）。
2010年7月至今中国科学院物理研究所软物质物理重点实验室工作。
主要研究方向：
主要从事物理学与生命科学交叉领域的研究，致力于用超高精度单分子荧光技术研究生物分子的运行机理。
过去的主要工作及获得的成果：
1.发展了精度达到的表面诱导荧光衰减方法，一举突破膜蛋白位置测量的技术瓶颈，可实时测量膜蛋白插膜的动力学。运用该方法，解析了多肽的跨膜过程。
2.发展了基于囊泡的荧光淬灭方法，此技术可以用于更为精确地研究接近真实生命过程的蛋白与膜相互作用的动态过程。
3.发展了DNA弓方法，用于提高单分子荧光共振能量转移的精度，应用该方法研究核酸酶，可以精确测量单个水解能量所驱动的分子马达在核酸上的运动，极大提高分子马达的研究能力。
代表性论文及专利：
1. Sodium Ion-Induced Structural Transition on the Surface of a DNA-Interacting Protein, Chunhua Xu#, Yue Lu#, Yichao Wu#, Shuaikang Yuan#, Jianbing Ma, Hang Fu, Hao Wang, Libang Wang, Hao Zhang, Xuan Yu, Wei Tao, Chang Liu, Shuxin Hu, Yi Peng, Wenfei Li*, Yunliang Li*, Ying Lu*, and Ming Li*, Adv. Sci., 2024, e2401838
2. Single-Molecule Monitoring of Membrane Association of the Necroptosis Executioner MLKL with Discernible Anchoring and Insertion Dynamics, Chenguang Yang#, Xiaolong He#, Hao Wang, Zhao Lin, Wenqing Hou, Ying Lu*, Shuxin Hu*, and Ming Li, Nano Letters, 2023, 23(11): 4770-4777
3. Identification of flexible Pif1-DNA interactions and their impacts on enzymatic activities, Jinghua Li#, Jianbing Ma#, Vikash Kumar#, Hang Fu, Chunhua Xu, Shuang Wang, Qi Jia, Qinkai Fan, Xuguang Xi, MingLi, Haiguang Liu*, and Ying Lu*, Nucleic Acids Res., 2022, 50(12): 7002–7012
4. RQC helical hairpin in Bloom's syndrome helicase regulates DNA unwinding by dynamically intercepting nascent nucleotides, Jianbing Ma#, Chunhua Xu#, Jinghua Li, Xi-Miao Hou, Lin-Tai Da, Qi Jia, Xingyuan Huang, Jin Yu, Xuguang Xi*, Ying Lu*, and Ming Li, iScience, 2022, 25(1): 103606
5. Subnanometer-Precision Measurements of Transmembrane Motions of Biomolecules in Plasma Membranes Using Quenchers in Extracellular Environment, Wenqing Hou#, Dongfei Ma#, Xiaolong He#, Weijing Han, Jianbing Ma, Hao Wang, Chunhua Xu, Ruipei Xie, Qihui Fan, Fangfu Ye, Shuxin Hu, Ming Li*, and Ying Lu*, Nano Lett., 2021, 21(1): 485-491
6. Dynamic structural insights into the molecular mechanism of DNA unwinding by the bacteriophage T7 helicase, Jian-Bing Ma#, Ze Chen#, Chun-Hua Xu#, Xing-Yuan Huang, Qi Jia, Zhen-Yu Zou, Chen-Yang Mi, Dong-Fei Ma, Ying Lu*, Hui-Dong Zhang*, and Ming Li, Nucleic Acids Res., 2020, 48(6): 3156-3164
7. Detecting Single-Molecule Dynamics on Lipid Membranes with Quenchers-in-a-Liposome FRET, Ma, D. F. Xu, C. H. Hou, W. Q. Zhao, C. Y. Ma, J. B. Huang, X. Y. Jia, Q. Ma, L. Diao, J. Liu, C*. Li, M*. Lu, Y*., Angew Chem Int Ed Engl, 2019, 58(17): 5577-5581
8. Ma, J. B., Jia, Q., Xu, C. H., Li, J. H., Huang, X. Y., Ma, D. F., Li, M., Xi, X. G., Lu, Y., Asynchrony of Base-Pair Breaking and Nucleotide Releasing of Helicases in DNA Unwinding, J Phys Chem B, 22, 5790-5796 (2018)
9. Wenxia Lin, Jianbing Ma, DaguanNong, Chunhua Xu, Bo Zhang, Jinghua Li, Qi Jia, Shuoxing Dou, Fangfu Ye, Xuguang Xi, Ying Lu, and Ming Li, "Helicase stepping Investigated with One-Nucleotide Resolution Fluorescence Resonance Energy Transfer", Phys. Rev. Lett., 119, 138102 (2017)
10. Ying Li, Zhenyu Qian, Li Ma, Shuxin Hu, DaguanNong, Chunhua Xu, Fangfu Ye, Ying Lu, Guanghong Wei, and Ming Li, " Single-molecule visualizationof dynamic transitions of pore-forming peptides among multiple transmembrane positions", Nat. Comm., 7, 12906 (2016)
11. Jinghua Li, Wenxia Lin, Bo Zhang, DaguanNong, Haipeng Ju, Jianbing Ma, Chunhua Xu, Fangfu Ye, Xuguang Xi, Ming Li, Ying Lu, and Shuoxing Dou, “Pif1 is a force-regulated helicase”, Nucleic Acids Res. 44, 4330-4339 (2016).
12. Shuang Wang, Wei Qin, Jinghua Li, Ying Lu, Keyu Lu, DaguanNong, Shuoxing Dou, Chunhua Xu, Xuguang Xi, and Ming Li, “Unwinding forward and sliding back: an intermittent unwinding mode of the BLM helicase”, Nucleic Acids Res. 43, 3736-3746 (2015)
13. Ying Lu, Shuxin Hu, and Ming Li, “Structure and Phase Transformation of Oligodeoxynucleotides/Lipid Lipoplexes on Solid-Supports”. Langmuir 26 ,3539 (2010).
目前的研究课题及展望：
1.研究离体和在体生物膜以及相关膜蛋白的动力学过程。
2.研究马达蛋白的动力学过程。
培养研究生情况：
拟每年招收研究生（硕博连读生或博士生）1-3名。
电话：
010-82648122
Email：